activated factor v การใช้

Thrombin activates Factor V by cleaving off the B domain.
It cleaves fibrinogen into fibrin monomers, activates Factor V, VIII, and XIII, allowing fibrin to develop a covalently cross-linked framework that stabilizes the thrombus.
Factors III and VI are unassigned, as thromboplastin was never identified, and actually turned out to consist of ten further factors, and accelerin was found to be activated Factor V.
Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation ( by degradating activated factor V ).
The thereby activated factor V ( now called FVa ) is a cofactor of the prothrombinase complex : The activated factor X ( FXa ) enzyme requires calcium and activated factor V to convert prothrombin to thrombin on the cell surface membrane.